Laser radiation is the best option compared to LED or pulse light radiation concerning photodynamic therapy (PDT) for skin cancer treatment, especially when high fluence (>5J/cm2) or localized tissue treatment is required. The topical agents 5 aminolevulinic acid (ALA) and its esterified compound Methyl Aminolevulinate (MAL) are among the most widely used nowadays, because they are excellent precursors of endogenous Protoporphyrin IX (PpIX), the photosensitizer involved in carcinogenic cell destruction. The optical absorption spectrum of PpIX shows its most outstanding band around 410nm. However, it also shows local maximum around 510, 540, 580 and 630nm. For this reason, diode laser radiation around 405nm would be the preferred option, but it is restricted to surface treatments due to the high absorption interference caused by haemoglobin or melanin. Besides, diode laser radiation around 635nm combines good absorption by PpIX and superior skin penetration. Altogether, makes 635nm the most suitable wavelength for PDT.
Monocrom provides solutions for laser-assisted PDT, involving low power (100mW) or high power (up to 10W) diode lasers emitting in the 635nm region. These elements can be assembled individually or creating customized arrays that can exceed output power densities greater than 2kW/cm2. Free-beam optics or fibre-coupling are also possible in all power ranges.
Fibre coupled module delivering 6W out of a SMA fibre with Ø 600 μm and NA 0.22
Absorption spectra of PpIX in chloroform (1 M solution)
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