Photodynamic Therapy

Our Lasers for Photodynamic Therapy

Photodynamic therapy (PDT) treatment involves a light source in combination with light-sensitive medicine to destroy abnormal and precancerous cells. This can be done non- or minimal-invasive.

Few parameters are important, when addressing PDT solutions. Parameters such as simplicity, high quality, low maintenance, reparability and cost optimized.

 

In Monocrom, we offer laser technology for Photodynamic Therapy based on Direct Diode Solutions in in 630nm, to meet the needs of the challenge in front. The solution is fiber delivered and cost effective.

LDM S serie

How PDT Lasers work?

The concept is to excite oxygen to its singlet state (1Δg), which is the lowest excitation possible, yielding in increased reactiveness of oxygen molecule. Oxidation and production of free radicals is a strong tool in cancer treatments. As tissue light penetration increases with wavelength, the treatment should address agents absorbing deep RED, such as chlorins, bacteriochlorins, and phthalocyanines. Addressing these agents allows improvement in tumour control. Especially, due to accelerated metabolism of fast growing tumour cells these agents automatically will be transported to the target area.

A solution for this treatment ideally should have high absorption range between 600 nm to 800 nm to ensure a high tissue penetration depth. In figure 1a (left side) the absorption spectra of protoporphyrin IX (short PPIX) is depicted, which is highly present in living organisms, and it has a strong absorption around 405 nm with a strong declining abs. value towards 450 nm. The excitation probability is almost negligible for wavelength longer than 600 nm, especially compared to its main abs. peak (405 nm). Figure 1b (right side) illustrates the oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) absorption spectrum in the visible and it clearly can be retrieved that the cut-off wavelength is around 600 nm. Thus, laser systems operating in the red region of light are preferable compared to other, shorter wavelengths.

monocrom laser cancer graph1

Figure 1a

monocrom laser cancer graph2

Figure 1b

Photodynamic Therapy Lasers / Technical specifications

Parameters

S6350-1C03

Wavelength [nm]

638 ± 5

Power [w]

Up to 500 mW

Cooling system

TEC

Pulse duration

CW

Repetition rate [Hz]

CW

Operating temperature [ºC]

10 – 45

Output beam [mm]

0.9 – 2

Output beam mode

TEM00 Circular

Related Products / Photodynamic Therapy

Discover our laser technology for Photodynamic Therapy. We also provide laser solutions to customer specific needs. Fill out the form below for more information.

Fiber-Coupled Lasers

Fiber-Coupled Lasers

Low and high power fiber-coupled diode lasers, based on diode laser stacks, mounted with Monocrom Solder-free laser bar Clamping™ technology.
Single Emitters

Single Emitters

Low power laser diode modules based on single emitters.

What are your application needs?

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